car-auto.nef6.com

Mar 1 2020

Cars from the side ) Video

#Cars #from #the #side



Cars from the side

*******

An advance in the groundbreaking cancer treatment known as CAR T-cell therapy appears to eliminate its severe side effects, making the treatment safer and potentially available in outpatient settings, a new USC study shows.

This is a major improvement,” said Si-Yi Chen of the USC Norris Comprehensive Cancer Center, professor in the Department of Molecular Microbiology and Immunology at the Keck School of Medicine of USC, and senior author of the study appearing online April 22 in Nature Medicine. “We’ve made a new CAR molecule that’s just as efficient at killing cancer cells, but it works more slowly and with less toxicity.”

This improved version of CAR T-cell therapy produced no serious side effects in 25 patients who had lymphoma that recurred after previous treatments. Although the study was designed to look at safety, not effectiveness, six out of 11 participants receiving a commonly used dose went into complete remission.

How CAR T-cell therapy works

CAR T-cell therapy involves harvesting immune cells called T cells from a patient’s blood and then modifying them in the lab to produce special structures called chimeric antigen receptors (CARs) on their surface. The altered T cells are reinfused into the patient, where the cells’ new receptors enable them to recognize and latch onto cancer cells, killing them.

Approved by the U.S. Food and Drug Administration less than two years ago, CAR T-cell therapy is a literal lifesaver for some people with leukemia and lymphoma, bringing lasting remissions to those on the brink of death. The downside is that the treatment often causes severe side effects — some of them life-threatening — which must be managed by experienced specialists.

These side effects occur when CAR T cells rapidly proliferate and release a flood of substances called cytokines. Severe cytokine release syndrome can lead to life-threatening multi-organ damage and brain swelling. In this revised version, researchers tweaked the sequence and shape of the CAR molecules. As a result, the CAR T cells kill cancer cells but produce fewer cytokines and proliferate more slowly, giving the patient’s body more time to clear cytokines in the blood.

“The improved CAR T cells proliferated and differentiated into memory cells in the patients, thus producing a potent and long-lasting anti-tumor effect without causing toxicities,” Chen said. “Toxicities are currently the biggest barrier to the use of CAR T-cell therapy. My hope is that this safer version of CAR T-cell therapy could someday be administered to patients in outpatient settings.”

Chen’s next step is to perform a multicenter phase II to test safety and effectiveness in a larger group of patients.

In addition to Chen, the study’s other authors are Xue F Huang, Xi Kang, Guan Wang, and Lindsey Jones, all of USC; Zhitao Ying, Ning Ding, Yuqin Song, Yufu Lin, Wen Zheng, Xiaopei Wang, Ningjing Lin, Meifeng Tu, Yan Xie, Chen Zhang, Weiping Liu, Lijuan Deng, Shunyu Gao, Lingyan Ping, Xuejuan Wang, Nina Zhou, and Jun Zhu, all of Peking University Cancer Hospital and Institute in Beijing; Xiaoyu Xiang, Yanling Liu, Xiaokai Guo, Hanzhi Liu, Tingting Zhang, Panpan Duan, Junqing Zhang, Yulong Wang, Songfeng Lin, Mierzhati Mamuti, Xueyun Yu, Lizhu Fang, Shuai Wang, and Haifeng Song of Marino Biotechnology Corp. in Beijing, China.

The study was supported financially by the Marino Biotechnology Corp., a private donation from Yi-Lin Zhu, and grants from the National Natural Science Foundation of China.

More stories about: Cancer, Health Care

Related stories

New research could prevent jaw damage in patients being treated for cancer or osteoporosis

The new technique could play a big part in eliminating osteonecrosis of the jaw, a currently incurable rare side effect of certain drugs.

Cancer drug shortages result in almost no treatment changes, USC study finds

Although the proportion of patients receiving treatment declined for six drugs, researchers found that the use of 32 other cancer drugs was unaffected or even increased during shortages.

New findings indicate additional benefits of exercise to breast cancer survivors

Study finds that patients who participated in a 16-week exercise program had a significantly reduced risk of developing cardiovascular disease over their sedentary counterparts.

Glowing deep-sea creatures inspire new cancer therapies

A new laboratory tool developed by USC researchers could improve the development and effectiveness of treatments that use patients’ immune systems to fight cancer.

Top stories on USC News

A winning weekend: Trojans claim conference titles in 4 sports

USC won conference championships in women’s beach volleyball and men’s tennis on Saturday, and women’s lacrosse and water polo on Sunday.

Trojan Marching Band selects first female drum major

India Anderson, a tuba player and junior in the USC Thornton School of Music, will lead the group for the 2019-2020 academic year.

USC’s track and field facility to undergo $16 million renovation

The first phase will include enlarged locker rooms and new lounge areas for the men‘s and women‘s teams.

****************************
SOURCE: http://news.usc.edu/156066/car-t-cell-therapy-side-effects/

Written by admin


%d bloggers like this: